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The Science of Beauty:

How growth factors rejuvenate skin

How growth factors rejuvenate skin

The science behind skin care has seen marked improvements in just the past few years alone. That’s because advanced research into biotechnology has revealed far more insights into understanding why skin changes over our lives, but more importantly, how we can create treatments that reverse the effects of aging, fade wrinkles and stretch marks and even heal scars.

But what’s even more exciting is that these breakthroughs have directed scientific research into a completely new direction, one that doesn’t rely on synthetic chemicals, but by unlocking the body’s natural healing abilities to stimulate our own cells to rejuvenate, restore, and rebuild skin.

Although the science may be complex, one basic theme is relatively easy to grasp. To rejuvenate and revitalize skin, we need skin cells to reproduce more quickly. New skin cells help fade lines and wrinkles, so the more rapidly we can encourage these cells to proliferate, the more likely it is that the treatment will be highly effective.

Although all of the cells in our bodies — from brain cells to muscle cells — die and are replaced by new cells every day, skin is especially vulnerable. Research shows that through natural abrasion, minor cuts we may not even be aware of, even moderate amounts of sunlight and other causes, we lose an average 30,000 to 40,000 skin cells per hour. That’s almost one million skin cells per day!

Growth factors: More skin cell proliferation to rejuvenate skin

Growth factors are proteins made in our bodies to regulate how and when cells reproduce. As we age, these growth factors may not work as quickly. With fewer skin cells, skin is not as flexible and as elastic, which not only results in lines and wrinkles, but also slows healing of scars.

Each type of cell may have a different set of growth factors based on specific proteins. For example, growth factors for brain cells are not the same as for cells of our skin, nor should they be. Cells are “differentiated” in that they specialize in certain biological functions. Indeed, the growth factors in dermal cells help us maintain thicker and more elastic skin — especially by stimulating collagen production — but those attributes may be completely irrelevant in nerve cells where growth factors play a different role.

How growth factors work in BioXskincare formulations

Based on decades of research and the expertise of scientists and dermatologists at BioXskincare's R&D lab, clinically-tested growth factors have been optimized to function as they naturally do, but with more healing potential. 


Because growth factors are proteins (cytokines) that regulate cellular growth under controlled conditions, they play an important part in wound repair and maintaining healthy skin structure and function — which is important to prevent signs of aging.


These growth factors are secreted by alpha granules present in specific botanical cells in response to cell signaling and extruded through the cell membrane. 


Histones and carbohydrates, which help in the selection and dispersion of pluripotent stem cells, are attached the emerging growth factors during this transfer. This enhances extracellular matrix repair, reconstruction, and restoration. 


For example, BioXskincare Scar Cream includes growth factors, mast cell inhibitors, proteolytic enzyme inhibitors, peptides, botanicals, algae’s, antioxidants, cell nutrients, anti-bacterials, anti-fungals and an osmotic tissue moisturizing system to stimulate collagen production and increase skin matrix density.

Botanical growth factors

The specific growth factors in BioXskincare skin creams that demonstrate high potential to restore normal skin structure, color, radiance, and elasticity include:

  • Transforming growth factor beta (TGF-B): Stimulates collagen secretion

  • Vascular endothelial growth factor (VEGF): Stimulates new blood vessel formation

  • Hepatocyte growth factor (HGF): Also stimulates new blood vessel formation

  • Keratinocyte growth factor (KFG): Stimulates epithelial cell growth

  • Interleukins (IL-6, IL-7, IL-8): Reduces inflammation

  • Basic fibroblast growth factor (bFGF): Promotes formation of new blood vessels

  • Insulin-like growth factor 1 (IGF1): Promotes cell growth and multiplication

  • Transforming growth factors (TGF-B2 and B3): Stimulates collagen secretion

  • Granulocyte monocyte colony stimulating factor: Increases the number of white cells.

There are many different types of growth factors (see box at right), and no single growth factor alone can rejuvenate and revitalize skin. Our formulas have been clinically-tested to balance the specific growth factors most essential to restoring normal skin architecture, color balance, radiance, and elasticity.

Unlocking natural healing within our own skin cells

In the time it took to read this article, you may have lost hundreds of skin cells just through normal biological processes alone. That’s how skin ages over time. But BioXskincare creams now unlock the power of natural botanical growth factors within our own bodies that demonstrate enormous anti-aging potential and the power to help renew and repair skin.

As our scientists and dermatologists continue their research, you can expect even further innovations so that more and more people worldwide can enjoy a healthier, more radiant, and youthful appearance.

Authored by

Alvin D. Needleman, Chief Scientific Officer, BioXskincare

As an internationally recognized innovator in cosmetic chemistry and pharmacology, Needleman has a 25-year track record for achieving pioneering breakthroughs in skin care science — developing more than 40 patented products and formulations. He has traveled across the world to identify indigenous botanical ingredients that demonstrate exceptional properties to rejuvenate skin. As Chief Science Officer, Needleman leads a team of anti-aging researchers dedicated to one singular mission — create all-natural skin care treatments that unlock the body’s natural healing power to deliver fast, long-lasting results.

These growth factors help promote healing, fade lines, and offer anti-aging properties because they:

  • Stimulate biochemical pathways that promote skin tissue repair and regeneration.

  • Promote collagen formation which helps skin remain more soft and supple

  • Interact with other proteins to help repair and regenerate skin

There are many different types of growth factors (see box at right), and no single growth factor alone can rejuvenate and revitalize skin. Our formulas have been clinically-tested to balance the specific growth factors most essential to restoring normal skin architecture, color balance, radiance, and elasticity.

The Science of Beauty:

How Growth Factors Work

See how BioXskincare is engineered to create lasting change.

Botanically Based Formulations

Our team has travelled across the globe in search of the highest-quality all-natural ingredients.

Deep Long-Lasting Skin Repair

Our formulations penetrate deeply into your skin offering far more effective and enduring results.

Find a BioXcellerator™ Certified Physician Near You.

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Most of the BioXskincare products described on this website are intended to meet the FDA's definition of a cosmetic product, an article applied to the human body to cleanse, beautify, promote attractiveness, and alter appearances. BioXskincare products are not intended to be drug products that diagnose, treat, cure, or prevent any disease or condition. These products have not been approved by the FDA and the statements on these pages have not been evaluated by the FDA.